Serum bilirubin levels are negatively associated with atherogenic lipids in Saudi subjects with type 2 diabetes: A pilot study

<b>Background: </b>Recent research has demonstrated the possible relevance of bilirubin in metabolic and cardiovascular disorders. Lipid abnormalities are a major problem that is related with an increased risk disease diabetics. This study examined relationship between serum direct concentrations atherogenic lipids patients type 2 diabetes (T2DM).<br /> <b>Methods</b>: cross-sectional included 67 39 matched healthy control. The lipid profile, including total cholesterol, HDL-C, TG levels, fasting blood glucose, bilirubin, ALT, AST, ALP were measured using dimension EXL clinical chemistry analyzer (Siemens Healthcare Diagnostics). Cholesterol VLDL, LDL, sdLDL calculated from standard assay results by equations Sampson et al.<br <b>Results</b>: Serum was lower non T2DM subjects nearly significant (p=0.0.51) whereas (p=0.008). levels higher groups. mean values LDL-C, sdLDL-C, HDL-C VLDL-C significantly group HDL-C. An inverse could be observed increase LDL-C (r<sup>2</sup>=0.139, p<0.005), sdLDL-C (r<sup>2</sup>=0.137, (r<sup>2</sup>=0.074, p<0.044), (r<sup>2</sup>=0.166, p<0.002) group. same (r<sup>2</sup>=0.133, p<0.006), (r<sup>2</sup>=0.172, p<0.001), (r<sup>2</sup>=0.118, p<0.01), (r<sup>2</sup>=0.182, p<0.001) group.<br <b>Conclusions</b>: A negative association found lipids, suggesting may protect development disease. These findings indicate need for additional large cohort.